Recent Announcements

1. ATAC-Seq data

posted Jul 20, 2020, 4:23 PM by Michael Cho

Link to lung cell ATAC data in both a Shiny/GViz app and IGV tracks.
Benway, Liu, et al, in preparation.

2. POLYGENIC RISK SCORE R CODE

posted May 27, 2020, 7:42 PM by Matthew Moll   [ updated Jul 20, 2020, 4:21 PM by Michael Cho ]

For our recent publication on polygenic risk scores for COPD, accepted to Lancet Respiratory Medicine, the R code can be found here: https://storage.googleapis.com/polygenicscores_copd/PolygenicScores_COPD.tar.gz

Instructions attached to this post.

3: ICGC / UK Biobank paper published

posted Jul 27, 2019, 5:08 PM by Michael Cho   [ updated Jan 27, 2020, 9:04 AM by Michael Cho ]

https://rdcu.be/borVd

Also:


Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.

Sakornsakolpat P, Prokopenko D, Lamontagne M, Reeve NF, Guyatt AL, Jackson VE, Shrine N, Qiao D, Bartz TM, Kim DK, Lee MK, Latourelle JC, Li X, Morrow JD, Obeidat M, Wyss AB, Bakke P, Barr RG, Beaty TH, Belinsky SA, Brusselle GG, Crapo JD, de Jong K, DeMeo DL, Fingerlin TE, Gharib SA, Gulsvik A, Hall IP, Hokanson JE, Kim WJ, Lomas DA, London SJ, Meyers DA, O'Connor GT, Rennard SI, Schwartz DA, Sliwinski P, Sparrow D, Strachan DP, Tal-Singer R, Tesfaigzi Y, Vestbo J, Vonk JM, Yim JJ, Zhou X, Bossé Y, Manichaikul A, Lahousse L, Silverman EK, Boezen HM, Wain LV, Tobin MD, Hobbs BD, Cho MH; SpiroMeta Consortium; International COPD Genetics Consortium.

Nat Genet. 2019 Mar;51(3):494-505. doi: 10.1038/s41588-018-0342-2. Epub 2019 Feb 25.


See also the wonderful paper in the same issue

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Shrine N, Guyatt AL, Erzurumluoglu AM, Jackson VE, Hobbs BD, Melbourne CA, Batini C, Fawcett KA, Song K, Sakornsakolpat P, Li X, Boxall R, Reeve NF, Obeidat M, Zhao JH, Wielscher M, Weiss S, Kentistou KA, Cook JP, Sun BB, Zhou J, Hui J, Karrasch S, Imboden M, Harris SE, Marten J, Enroth S, Kerr SM, Surakka I, Vitart V, Lehtimäki T, Allen RJ, Bakke PS, Beaty TH, Bleecker ER, Bossé Y, Brandsma CA, Chen Z, Crapo JD, Danesh J, DeMeo DL, Dudbridge F, Ewert R, Gieger C, Gulsvik A, Hansell AL, Hao K, Hoffman JD, Hokanson JE, Homuth G, Joshi PK, Joubert P, Langenberg C, Li X, Li L, Lin K, Lind L, Locantore N, Luan J, Mahajan A, Maranville JC, Murray A, Nickle DC, Packer R, Parker MM, Paynton ML, Porteous DJ, Prokopenko D, Qiao D, Rawal R, Runz H, Sayers I, Sin DD, Smith BH, Soler Artigas M, Sparrow D, Tal-Singer R, Timmers PRHJ, Van den Berge M, Whittaker JC, Woodruff PG, Yerges-Armstrong LM, Troyanskaya OG, Raitakari OT, Kähönen M, Polašek O, Gyllensten U, Rudan I, Deary IJ, Probst-Hensch NM, Schulz H, James AL, Wilson JF, Stubbe B, Zeggini E, Jarvelin MR, Wareham N, Silverman EK, Hayward C, Morris AP, Butterworth AS, Scott RA, Walters RG, Meyers DA, Cho MH, Strachan DP, Hall IP, Tobin MD, Wain LV; Understanding Society Scientific Group.

Nat Genet. 2019 Mar;51(3):481-493. doi: 10.1038/s41588-018-0321-7. Epub 2019 Feb 25. Erratum in: Nat Genet. 2019 Jun;51(6):1067.

PMID:
 
30804560

5. Genetic overlap of cardiovascular related traits

posted Jul 27, 2019, 5:06 PM by Michael Cho   [ updated Jan 20, 2020, 5:04 PM by Michael Cho ]

Genetic overlap of chronic obstructive pulmonary disease and cardiovascular disease-related traits: a large-scale genome-wide cross-trait analysis.

Zhu Z, Wang X, Li X, Lin Y, Shen S, Liu CL, Hobbs BD, Hasegawa K, Liang L; International COPD Genetics Consortium, Boezen HM, Camargo CA Jr, Cho MH, Christiani DC.

Respir Res. 2019 Apr 2;20(1):64. doi: 10.1186/s12931-019-1036-8.

6. ICGC and the Lung Tissue Transcriptome published

posted Jul 27, 2019, 5:04 PM by Michael Cho   [ updated Jan 20, 2020, 5:04 PM by Michael Cho ]

Leveraging lung tissue transcriptome to uncover candidate causal genes in COPD genetic associations.

Lamontagne M, Bérubé JC, Obeidat M, Cho MH, Hobbs BD, Sakornsakolpat P, de Jong K, Boezen HM; International COPD Genetics Consortium, Nickle D, Hao K, Timens W, van den Berge M, Joubert P, Laviolette M, Sin DD, Paré PD, Bossé Y.

Hum Mol Genet. 2018 May 15;27(10):1819-1829. doi: 10.1093/hmg/ddy091.


7. First ICGC Genetics paper accepted

posted Nov 24, 2016, 4:36 AM by Michael Cho   [ updated Jan 20, 2020, 5:02 PM ]

Our first paper has been accepted by Nature Genetics!  Thanks to all that made this happen.
Sharable link here:
http://rdcu.be/o3An

4. New URL

posted Aug 31, 2016, 12:40 PM by Michael Cho   [ updated Jan 20, 2020, 5:04 PM ]

We now redirect from www.copdconsortium.org.

8: Genetics cohort list

posted Jul 31, 2014, 7:52 AM by Michael Cho   [ updated Jan 20, 2020, 5:01 PM ]

Please take a look at the cohort list (found here: Genetics-Project documents) and update.
Minutes from the previous call now on the website.

9: Introduction to the site

posted Jan 23, 2013, 10:44 AM by Manisha Kumbhojkar   [ updated Jan 20, 2020, 5:01 PM by Michael Cho ]

Hello!!
 
Welcome to the ICGC site. Pls feel free to navigate through the website. We would love to know your feedback:). Thank You.
 
 

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